Nhazi ihe eji emepụta ihe ọhụrụ

Mgbakọ onwe onye nke molekụla

--kemistri akwụkwọ ndụ akwụkwọ ndụ nke na-enweghị mmebi njikọ na njikọta

Isi ụkpụrụ nke nchikọta onwe onye nke molekul:

1. Dị ka ihe na-adọta - ịkwọ ihe ndị yiri ya iji chịkọta ma hazie ibe ha, yana ihe ndị nwere ihe ndị ọzọ iji dọta ibe ha.

2. Ike kachasị ala—mmegharị ihe na omume molekul ga-adị ka ọnọdụ kachasị kwụsie ike. Ọ bụ ụzọ e si hazie otu molekul n'ime usoro dị elu.

Nhazi onwe onye nke molekul, nhazi CP n'etiti molekul nwere ike imeziwanye ọrụ ndu nke ukwuu:

1. Mkpụrụ ndụ ihe nketa ọ bụla nwere nhazi na njirimara ọrụ ya pụrụ iche, ọ na-esikwa ike inweta mmekorita na ọgwụgwọ ziri ezi dabere na ngwakọta efu na ọkwa nhazi.

2. E ka nwere ọtụtụ molekul nwere ọrụ bayoloji dị mma nke mere ka mmịpụta na itinye ha n'ọrụ belata nke ukwuu n'ihi àgwà ọjọọ ha.

3. Ihe ndị dị n'ọgwụ ọdịnala nke ndị China na-arụ ọrụ nke ọma gbasara "eze ukwu, ndị minista na ndị enyemaka", kama ịbụ hodgepodge nke ka mma.

Ụdị usoro nyocha nhazi na nhazi nke supramolecular:

1. Nnyocha ngwa ngwa nke kọmputa nyere aka maka inyocha ngwa ndị kwesịrị ekwesị site na Cambridge Crystal Data Center.

2. Jiri ozizi ọrụ njupụta mụọ nhazi na ihe ndị mejupụtara supramolecular nke ike intermolecular kpebiri, ma chọpụta ụdị supramolecular nke bụ usoro nhazi.

3. Site n'inyocha ọnọdụ mmeghachi omume na ihe isi ike, e mere ka nhazi supramolecular dịkwuo mma.

4. Ngụkọta nke ihe dị iche iche nke supramolecules, gụnyere ihe ndị metụtara eletriki, anya na thermodynamic.

5. Ngụkọta nke ihe ndị dị ka spectral spectrum na ike spectrum.

6. Site na teknụzụ docking molekul, a na-ebu amụma banyere ebe mmekọrịta dị n'etiti ihe ndị dị n'elu ihe na protein ndị a na-elekwasị anya, a na-akọwakwa usoro mmekọrịta dị n'etiti molekul n'ụzọ miri emi.

Teknụzụ nnu supramolecular eutectic/Ionic

Atụmatụ teknụzụ: nke mbụ n'ime ụlọ ọrụ ahụ, na-enyocha ihe kacha mma CP nke ihe ndị na-arụ ọrụ maka ime ka eutectic sie ike

Uru: belata iwe, melite mgbaze, melite ọrụ, kwalite permeability, melite nkwụsi ike

Ihe atụ nke ihe ndị mejupụtara ya: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

Ihe ndị sitere n'okike e si na katalọgụ ihe ịchọ mma mee, mgbe anwalechara ule dịka simulation kemịkalụ quantum, nyocha dị elu, optimization Gaussian, KingDraw, MestReNova, FTIR, na NMR, ngwaahịa ndị e nwetara nwere nhazi kristal atọ dị mma, ezigbo nkwụsi ike, ịdị ọcha dị elu, enweghị ihe ruru unyi. Ọ nwere ike idozi isi ihe mgbu nke ihe ndị dị na nri, ọgwụ na ihe ịchọ mma nke ọma, ma melite bioavailability na nchekwa nke ihe ndị dị na ọrụ.

Teknụzụ mwepụta ọrụ supramolecular

Atụmatụ teknụzụ: Nke mbụ nke ụlọ ọrụ ahụ, njikọta nke teknụzụ ntinye ihe na ihe mgbaze eke nke supramolecular, mwepụta dị irè nke ihe ndị na-arụ ọrụ osisi

Uru: A na-eme ka mwepụta ahụ dịkwuo elu ugboro ise ma e jiri ya tụnyere mwepụta mmanya na-aba n'anya, a na-emekwa ka mwepụta mmiri dịkwuo elu ugboro iri abụọ; enweghị nkewa, mbelata ọnụ ahịa, ihe ndị na-akwalite ntinye aka. Ihe atụ: olive (oleuropein, hydroxytyrosol), rhodiola, Phyloporus ọgwụ, lily mmiri ọcha, micrococcus

Ihe mgbaze miri emi nke eutectic sitere n'okike (NaDES): Ndị ọkà mmụta sayensị chọpụtara ya na mbụ na nyocha nke metabolomics nke osisi. N'oge ụfọdụ nke mmepe nke osisi (ịmịpụta mkpụrụ, cryopreservation), mkpụrụ ndụ ga-etolite mmiri mmiri siri ike nke na-enweghị mmiri na lipids, nke yiri ngwakọta nke eutectics.

Dabere na teknụzụ nkewa akwụkwọ ndụ akwụkwọ ndụ nke oge a, teknụzụ akpụkpọ ahụ agbakwunyere, nke teknụzụ mmụba ultrasonic / microwave na-emeju iji nweta obere okpomọkụ, ebumnuche, ịdị elu, ịdị mma dị elu na mwepụ akwụkwọ ndụ akwụkwọ ndụ nke ihe ndị na-arụ ọrụ. Site na ihe mgbaze supramolecular eke dị ka ihe mgbaze mmepụta arụmọrụ, ọ na-edozi ọtụtụ nsogbu dịka obere arụmọrụ, ọnụ ahịa dị elu na ihe isi ike na mgbake mmiri mkpofu nke mwepụ phytochemical ọdịnala. Ahọpụtala ihe mgbaze supramolecular ewepụtara maka arụmọrụ ha. Ihe mgbaze supramolecular ahọpụtara nwere arụmọrụ kwụsiri ike na mmụba nke ihe ndị na-arụ ọrụ, yana arụmọrụ mwepụta nwere ike ịbawanye ugboro 20.

Teknụzụ ntinye aka na Supramolecular synergistic

Atụmatụ teknụzụ: Nke mbụ ụlọ ọrụ ahụ, site na ihe mgbaze supramolecular, na-akwalite ịbanye n'ime macromolecules/nke na-agbaze mmiri/nke siri ike ịmịkọrọ ihe ndị e ji mee ya.

Uru teknụzụ: mmezi siri ike, mmụba nke ntinye aka na-adịghị emebi emebi na nke dị irè, mmetụta synergistic, mmụba ntụziaka na akpụkpọ ahụ, na bioavailability mụbara site na ugboro 5-7 Ihe atụ ndị dị na ya: collagen, Bosein, peptide ọla kọpa acha anụnụ anụnụ, hexapeptide, peptide compound, β-glucan.

Ebe ọ bụ na ibu molekul nke peptide ka buru ibu ma e jiri ya tụnyere ihe ndị ọzọ na-arụ ọrụ, ntinye akpụkpọ ahụ dị obere. A chọrọ ụfọdụ ụzọ na-eme ka ntinye dịkwuo mma iji melite mmetụta ntinye nke peptide ahụ, iji nweta obere ntinye na arụmọrụ dị elu, ma nweta arụmọrụ ka mma megide ịka nká.

N'ihi nsogbu dị n'ime ụlọ ọrụ ahụ nke enweghị ike ịbanye n'ime, oke mmiri na obere bioavailability nke macromolecules ọdịnala, njikọta ngwaahịa JUNAS Time Particle site na kemistri quantum na-enyere aka, nwere ike iru epidermis na dermis nke akpụkpọ ahụ ozugbo site na trans-cellular, intercellular na follicular duct ducts. Na-emebighị nhazi akpụkpọ ahụ. A na-amụba bioavailability nke ngwaahịa ahụ ugboro ise, gụnyere ihe karịrị 45% na dermis, na-emebighị nhazi akpụkpọ ahụ. Mmetụta ịbanye na oge obibi enwetawo ọganihu dị ukwuu. Nke a bụ nke mbụ n'ụdị ya na ụlọ ọrụ ahụ.

Teknụzụ biocatalysis supramolecular

Nkatọ nke bioenzyme na-eduzi: A na-eji ihe mgbaze supramolecular eme ihe dị ka ihe ndị na-eme ka ọrụ enzyme dịkwuo mma, melite nhọrọ chiral, ma nweta ịdị ọcha dị elu.

Injinia fennel green fermentation: họrọ osisi njirimara, melite ọdịnaya nke ihe ndị na-arụ ọrụ, usoro anhydrous, melite arụmọrụ zuru oke

Teknụzụ ịgbara mmiri micellar azụ: inyocha ụdị njirimara, mmanụ akwụkwọ nri na-agba agba, mmetụta ndị ọzọ, ime ka akpụkpọ ahụ dịkwuo mma ma melite mmịpụta

Dabere na teknụzụ mkpụrụ ndụ ihe nketa recombinant, teknụzụ cloning mkpụrụ ndụ ihe nketa otu nzọụkwụ na teknụzụ catalytic bioenzyme dị elu, a na-eji nje bacteria emepụtara mkpụrụ ndụ ihe nketa dị ka ndị na-ebu catalytic iji mepụta nnukwu mmepụta nke ihe ndị na-arụ ọrụ:

N'okpuru sistemụ ihe mgbaze supramolecular, enzyme ahụ na-egosi ọrụ dị elu, nhọrọ na nkwụsi ike, ojiji dị elu nke ihe ndị e ji ihe ndị dị n'okpuru ala, obere mmetọ na usoro mmepụta, ọnọdụ mmeghachi omume dị nro, arụmọrụ nchekwa dị elu na arụmọrụ mmepụta.

Teknụzụ ịgba micelle azụ:

A na-emepụta mmanụ eke ahọpụtara nwere njirimara ndị China lP n'onwe ya iji mepụta surfactants n'okpuru ọrụ nke nje bacteria e ji mkpụrụ ndụ ihe nketa mepụta. A na-achịkọta ya dị ka onye na-ebu ngwugwu anti-micellar iji mezuo mkpuchi mgbochi-micellar nke ihe ndị na-arụ ọrụ mmiri na-agbaze iji nweta ọnọdụ ngwa bara ụba, ahụmịhe akpụkpọ ahụ kachasị mma, na arụmọrụ dị ịrịba ama, ahụmịhe, na arụmọrụ dị ukwuu.

Teknụzụ supramolecular microencapsulation

Njirimara teknụzụ: liposome encapsulation, ntọhapụ nke mkpụrụ ndụ akpụkpọ ahụ ezubere iche, ntọhapụ nke follicles ntutu ezubere iche, na mwepụta nke ihe ndị na-akpata mbufụt na-aza aza

Uru: Nanoization, nnyefe ziri ezi, ntọhapụ na-adịgide adịgide, ibelata mgbakasị ahụ, ime ka nkwụsi ike dịkwuo mma, na ịkwalite ikike mmadụ ịbanye n'ime mmiri

Ihe atụ nke ihe ndị e ji mee ya: astaxanthin, glabridin, vitamin A, peptide ọla kọpa anụnụ anụnụ, biotin, ceramide, mmanụ dị mkpa nke osisi

Teknụzụ supramolecular microencapsulation dabere na liposome, emulsion abụba, teknụzụ ionic liquid stabilization, teknụzụ ntọhapụ ezubere iche maka mkpụrụ ndụ akpụkpọ ahụ, teknụzụ ntọhapụ follicle ntutu isi, na teknụzụ mwepụta ihe mkpali na-anabata ihe mkpali. Site n'ịmepụta ọwa njem arụrụ arụ, ngwaahịa a nwere ike inye ihe ndị dị mkpa kpọmkwem. Ọ nwere oke nnabata transdermal dị mma, ogologo oge obibi na ezigbo nkwụsi ike na ebe akpụkpọ ahụ lekwasịrị anya. Ọ nwekwara obere ọnụ ahịa na arụmọrụ dị elu n'ọhịa nke ihe ịchọ mma, nri bara uru na ọgwụ.

Teknụzụ nhazi onwe nke peptide

Atụmatụ teknụzụ: nhazi mbụ nke ụlọ ọrụ ahụ, nke ezubere iche maka nhazi ọtụtụ ọkwa nke yinye amino acid na polypeptides, peptides dị mkpụmkpụ nke ejiri aka ha hazie onwe ha, polypeptides supramolecular

Ntuziaka teknụzụ: Meziwanye amphiphilicity, melite nkwụsi ike na iguzogide okpomọkụ, belata nsí na nrụgide mgbochi ọrịa, kwalite mmịpụta, ma mee ka njikọta dịkwuo mma

Ihe atụ nke ihe ndị mejupụtara ya: supramolecular carnosine, yist protein peptide

Nchịkọta onwe onye nke protein na peptides abụghị naanị ihe a na-ahụkarị n'ime usoro ndụ, kamakwa ọ bụ ihe dị mma maka ahụ mmadụ, ọ bụkwa otu n'ime ụzọ dị irè isi mepụta ihe nano-biological. Usoro nhazi onwe nke peptide bụ usoro nhazi hierarchical, "usoro zipa polar amino acid" bụkwa ụdị nhazi ọhụrụ nke super-secondary, nke na-enyere aka na mgbakọ hierarchical nke peptides iji mepụta mkpokọta ndị a haziri ahazi.

Enwere ike ime ka nha peptides dị mkpụmkpụ gbanwee site n'ịgbanwe hydrophobicity na njikọ akụkụ nke ihe fọdụrụ hydrophobic.

Dabere na nchekwa data pụrụ iche nke Shinehigh Innovation's ProteinDataBank (PDB), jikọta ya na nlele nnwale sistemụ, molekul dynamics na mgbakọ na mwepụ nke quantum iji nyochaa nhazi nke peptide molecules, wee jikọta ha na molekul chịkọta onwe-ha dị elu. Mgbanwe nke ụdị, ọnụọgụ na ọnọdụ mmekọrịta nke amino acid n'etiti peptide molecules iji gbanwee nhazi mpịachi ha kpọmkwem, si otú a na-eme ka ikike nke molekul ahụ iji chịkọta onwe ya ka mma. Mezue nhazi ezubere iche nke peptides. Peptide nke a na-ejikọta onwe ya nwere amphiphilicity na symmetry dị mma, nke na-eme ka nkwụsi ike peptide, ikike transdermal na bioavailability dịkwuo mma.