Nhazi akụrụngwa ohuru ohuru

Mkpokọta onwe onye

--kemịkalụ akwụkwọ ndụ akwụkwọ ndụ n'ókè na-enweghị nkwụsị nke njikọ na njikọ ọzọ

Ụkpụrụ bụ isi nke nchikota onwe ha:

1. Dị ka-adọta dị ka - ịnya ụgbọ ala yiri bekee na-achịkọta na ndokwa onye ọ bụla ọzọ, na bekee na nkwado Njirimara na-adọta ọ bụla ọzọ.

2. The kasị ala ume-okwu ije na molekụla omume ga-emekarị ka ndị kasị kwụsie ike ọnọdụ. Ọ bụ ụzọ a ga-esi hazie otu dị iche iche mkpụrụ ndụ ka ha bụrụ ihe owuwu dị elu.

Nhazi onwe-nhazi nke molecular, usoro CP n'etiti ụmụ irighiri ihe nwere ike imeziwanye ọrụ ndu:

1. Molecule ọ bụla nwere usoro ya pụrụ iche na ihe ndị na-arụ ọrụ, ọ na-esikwa ike iji nweta synergy na ọgwụgwọ ziri ezi dabere na ngwakọta n'efu na ọkwa nhazi.

2. A ka nwere ọtụtụ ụmụ irighiri ihe nwere ezigbo ọrụ ndu nke kpachapụrụ oke nnabata na itinye ha n'ọrụ n'ihi njirimara ọjọọ ha.

3. Ihe na-arụsi ọrụ ike nke ọgwụ ndị China ọdịnala bụ ihe gbasara "eze, ndị ozi na ndị na-enyere aka", karịa hodgepodge nke ka mma.

Nhazi usoro nyocha nke Supramolecular na usoro nyocha kacha mma:

1. Kọmputa na-enyere aka na-enyocha ihe ntanetị dị elu maka nyocha ngwa ngwa nke ndị na-ebute ụzọ kwesịrị ekwesị site na Cambridge Crystal Data Center.

2. Jiri njupụta ọrụ tiori na-amụ usoro supramolecular na mkpokọta Njirimara kpebisiri ike intermolecular agha, na-ekpebi nke supramolecular ụdị bụ guzobe na-emekarị.

3. Site n'inyocha ọnọdụ mmeghachi omume na ihe isi ike, a na-emezi usoro supramolecular kachasị.

4. Ngụkọta ihe dị iche iche nke supramolecules, gụnyere eletriki, ngwa anya na thermodynamic Njirimara.

5. Ngụkọta ihe ndị na-ahụ anya dị ka molecular spectrum na ume spectrum.

6.Site na teknụzụ docking molekụla, saịtị mmekọrịta dị n'etiti akụrụngwa supramolecular na protein lekwasịrị anya na-ebu amụma, na usoro mmekọrịta dị n'etiti ụmụ irighiri ihe akọwara n'ime omimi.

Nkà na ụzụ nnu nke supramolecular eutectic/Ionic

Nrụ ọrụ nka: nke mbụ ụlọ ọrụ, na-enyocha akụkụ CP kacha mma nke akụrụngwa na-arụ ọrụ maka ike eutectic

Uru: belata iwe, kwalite solubility, melite ọrụ, kwalite permeability, melite nkwụsi ike

Ihe atụ nke ihe eji eme ihe: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

Ngwakọta anụ ahụ na-arụ ọrụ sitere na katalọgụ nke akụrụngwa ịchọ mma, mgbe nnwale nyocha dị ka simulation kemịkalụ, nyocha dị elu, njikarịcha Gaussian, KingDraw, MestReNova, FTIR, na NMR, ngwaahịa ndị enwetara nwere ọmarịcha kristal akụkụ atọ, nkwụsi ike dị elu, ịdị ọcha dị obere, adịghị ọcha. Ọ nwere ike dozie isi ihe mgbu ngwa ngwa nke ihe ndị na-arụ ọrụ na nri, ọgwụ na ihe ịchọ mma, ma melite bioavailability na nchekwa nke ihe ndị na-arụ ọrụ.

Teknụzụ mmịpụta ihe omume Supramolecular

njiri mara: Nke mbụ nke ụlọ ọrụ ahụ, nchikota teknụzụ na-emetụta mkpụrụ ndụ na ihe mgbaze supramolecular eke, mmịpụta nke ọma nke ihe ọkụkụ na-arụ ọrụ nke ọma.

Uru: Mwepụta ezubere iche, nrụpụta mmịpụta na-abawanye ugboro 5 ma e jiri ya tụnyere mmịpụta mmanya, na mmịpụta mmiri na-abawanye ugboro 20; enweghị nkewa, mbelata ọnụ ahịa, ihe na-akwalite ntinye ihe atụ: olive (oleuropein, hydroxytyrosol), rhodiola, Phyloporus ọgwụ, lily mmiri ọcha, micrococcus.

Natural deep eutectic solvent (NaDES): Ndị ọkà mmụta sayensị chọpụtara ya na mbụ na nyocha nke metabolomics osisi. N'ime oge mmepe ụfọdụ nke osisi (germination, cryopreservation), mkpụrụ ndụ ga-etolite n'otu ntabi anya mmiri mmiri viscous na-adabere na mmiri na lipids, dị ka ngwakọta nke eutectics.

Dabere n'oge a green nkewa technology, integrated akpụkpọ technology, complemented site ultrasonic / ngwa ndakwa nri technology nweta ala okpomọkụ, ezubere iche, elu ciency, elu àgwà na green mmịpụta nke nọ n'ọrụ components.Through na eke supramolecular mgbaze dị ka irè mmịpụta ihe mgbaze, ọ na-edozi ọtụtụ nsogbu ndị dị otú ahụ dị ka obere arụmọrụ, elu na-eri na ike na n'efu mmiri mmiri mgbake nke omenala phymolecular arụpụtaghị ihe ahọrọ. Ihe mgbaze supramolecular ahọpụtara nwere arụmọrụ kwụsiri ike yana nkwalite solubility nke ihe ndị na-arụ ọrụ, enwere ike ịbawanye arụmọrụ mmịpụta site na ugboro 20.

Nkà na ụzụ ntinye aka nke supramolecular

Nka na ụzụ atụmatụ: The ụlọ ọrụ nke mbụ, site na supramolecular mgbaze synergistically na-akwalite penetration nke macromolecules/mmiri soluble / siri ike ịmịkọrọ Efrata

Uru nka: nkwụsi ike ka mma, nkwalite ntinye nke na-adịghị emebi emebi na nke ọma, mmetụta synergistic, nkwalite ntụziaka na dermis, na bioavailability mụbara site na 5-7 ugboro ihe atụ: collagen, Bosein, peptide ọla kọpa na-acha anụnụ anụnụ, hexapeptide, peptide compound, β-glucan.

Ebe ọ bụ na arọ molekụla nke peptide ka dị ntakịrị ma e jiri ya tụnyere ihe ndị ọzọ na-arụ ọrụ, ntinye akpụkpọ ahụ dị ntakịrị. Ụfọdụ ụzọ na-eme ka ntinye ntinye dị mkpa iji kwalite mmetụta nnabata nke peptide na-eme ka ọ dịkwuo mma, ka o wee nweta ntanye dị ala na ịdị elu dị elu, wee nweta mmetụta mgbochi ịka nká ka mma.

Na nzaghachi na ụlọ ọrụ akpịrị ebe nke ogbenye penetration, elu hydrophilicity na ala bioavailability nke omenala macromolecules, na JUNAS Time urughuru ngwaahịa synthesis via quantum kemịkalụ aka, nwere ike ozugbo iru epidermis na dermis nke akpụkpọ site trans-cellular,intercellular na follicular ọsụsọ ductchannels. Na-emebighị usoro akpụkpọ ahụ. The bioavailability nke ngwaahịa na-abawanye site na 5 ugboro, gụnyere ihe karịrị 45% na dermis, na-enweghị imebi akpụkpọ Ọdịdị. The penetration mmetụta na ibi ndụ na-enwetala ọganihu dị ịrịba ama. Nke a bụ nke mbụ ụdị ya na ụlọ ọrụ.

Teknụzụ biocatalysis nke supramolecular

Bioenzyme na-eduzi catalysis: a na-eji ihe mgbaze supramolecular mee ihe dị ka ihe na-eme ka ọrụ enzyme kwalite, kwalite nhọrọ chiral, ma nweta ịdị ọcha dị elu.

Injinia fennel green gbaa ụka: họrọ osisi mara mma, welie ọdịnaya nke ihe ndị na-arụ ọrụ, usoro anhydrous, melite arụmọrụ niile.

Teknụzụ fermentation micellar na-atụgharị: nyocha ụdị njirimara, mmanụ ihe oriri na-eko achịcha, mmetụta ndị ọzọ, na-eme ka ahụ dịkwuo mma na ịkwalite nnabata.

Dabere na teknụzụ recombinant gene technology, otu nzọụkwụ gene cloning technology na elu-njupụta bioenzyme catalytic technology, genetically engineered bacteria na-eji dị ka catalytic ebu iji ghọta na nnukwu-ọnụ ọgụgụ mmepụta nke nọ n'ọrụ bekee:

N'okpuru sistemu ihe mgbaze supramolecular, enzyme na-egosi ọrụ dị elu, nhọrọ na nkwụsi ike, ojiji dị elu nke akụrụngwa akụrụngwa, obere mmetọ na usoro mmepụta, ọnọdụ mmeghachi omume dị nro, arụmọrụ nchekwa dị elu na arụmọrụ mmepụta.

Ntugharị teknụzụ fermentation micel:

ahọrọ eke mmanụ na Chinese e ji mara lP na-spontaneously e mere na-emepụta surfactants n'okpuru omume nke genetically engineered bacteria.lt na-agbakọta dị ka ụgbọelu nke mgbochi micellar ukwuu ịghọta mgbochi-micellar ngwugwu wrapping nke mmiri-soluble arụ ọrụ Efrata iji nweta ọgaranya ngwa ndapụta, ikpeazụ akpụkpọ ahụmahụ, na ịrịba, ahụmahụ na dị ịrịba ama, arụmọrụ.

Teknụzụ microencapsulation nke supramolecular

Nrụ ọrụ nka: mkpuchi liposome, ntọhapụ ezubere iche nke mkpụrụ ndụ dermal, ntọhapụ nke ntutu isi ezubere iche, na ntọhapụ nke ihe mkpali.

Uru: Nanoization, nnyefe ziri ezi, ntọhapụ na-adịte aka, ibelata iwe, melite nkwụsi ike, na ịkwalite ikike.

Ihe atụ nke ihe eji eme ihe: astaxanthin, glabridin, vitamin A, peptide ọla kọpa na-acha anụnụ anụnụ, biotin, ceramide, mmanụ dị mkpa osisi.

Supramolecular microencapsulation technology dabeere na liposome, abụba emulsion, ionic liquid stabilization technology, dermal cell ezubere iche ntọhapụ technology, ntutu follicle ezubere iche ntọhapụ technology, na mkpali ihe na-anabata ntọhapụ technology.Site na-eke artificial iga ọwa, ngwaahịa nwere ike na-anapụta ndị na-arụ ọrụ Efrata kpọmkwem. Lt nwere oke nnabata transdermal, ogologo oge na nkwụsi ike na ebe ebumnuche akpụkpọ ahụ. Ọ na-enwekwa ọnụ ala na ngwa dị elu dị elu n'ọhịa nke ịchọ mma, nri na-arụ ọrụ na ọgwụ.

Teknụzụ nhazi onwe nke Peptide

Njirimara teknụzụ: nke mbụ nke ụlọ ọrụ ahụ, ụkpụrụ ezubere iche nke usoro nhazi nke agbụ amino acid na polypeptides, peptides dị mkpụmkpụ gbakọtara onwe ya, polypeptides supramolecular.

Ntuziaka teknụzụ: Meziwanye amphiphilicity, welie nkwụsi ike na nkwụsi ike okpomọkụ, belata nsị na nrụgide mgbochi, kwalite nnabata, na imekọrịta ihe.

Ọmụmaatụ nke ihe mejupụtara: carnosine supramolecular, protein peptide yiast

Nchikota nke protein na peptides abụghị naanị n'ebe niile na usoro ndụ, kamakwa ọ bụ ihe magburu onwe ya maka ahụ mmadụ, yana otu n'ime ụzọ dị irè maka ịmepụta nano-biological material. Usoro nchikota onwe nke peptide bụ usoro mgbakọ ndị isi, yana "polar amino acid zipper structure" bụ ụdị ọhụrụ nke nnukwu ụlọ akwụkwọ sekọndrị, nke na-enyere aka na mgbakọ ndị peptides na-achịkọta ọnụ iji mepụta nchịkọta iwu.

Enwere ike nweta ụkpụrụ nduzi nke nha peptides dị mkpụmkpụ site n'ịgbanwe hydrophobicity na n'akụkụ yinye alaka nke hydrophobic residues.

Dabere na Shinehigh Innovation si pụrụ iche ProteinDataBank (PDB) nchekwa data, ikpokọta na Ịhazi nnwale chọpụtara, molecular dynamics na quantum chemistry mgbako iji nyochaa Ọdịdị nke peptide ụmụ irighiri ihe, na mgbe ahụ dakọtara ha na elu-throughput onwe-mgbakọ molecules.Modulation nke ụdị, ọnụ ọgụgụ na ikwu kpọmkwem ọnọdụ nke amino acid molecules. si otú ahụ na-emeziwanye ikike nke molekul iji chịkọta onwe ya. Chọpụta ụkpụrụ ezubere iche nke peptides. Ihe peptide na-agbakọta onwe ya nwere ọmarịcha amphiphilicity na symmetry, nke na-eme ka nkwụsi ike peptide dị ukwuu, ikike transdermal na bioavailability.