RJMPDRN®REC na-anọchite anya ọganihu dị ukwuu na ihe ịchọ mma dabere na nucleic acid, na-enye azụ salmon PDRN nke a na-emepụta site na teknụzụ bayotechnoloji. A na-ewepụta PDRN ọdịnala site na azụ salmon, usoro nke ọnụ ahịa dị elu na-egbochi, mgbanwe dị iche iche n'otu oge, na ịdị ọcha pere mpe. Ọzọkwa, ịdabere na akụrụngwa okike na-akpata nchegbu maka nkwado gburugburu ebe obibi ma na-egbochi oke nha iji gboo mkpa ahịa na-eto eto.
RJMPDRN®REC na-edozi nsogbu ndị a site n'iji nje bacteria e mepụtara emepụta iji mepụta iberibe PDRN ndị a na-elekwasị anya, na-eme ka mmepụta ahụ nwee ike ịchịkwa ma na-ejigide ịdị mma a na-emegharị emegharị ma na-ebelata mmetụta gburugburu ebe obibi.
Usoro a nke na-eme ka e nwee ike ịhazi usoro ọrụ nke ọma, na-eme ka e nwee ngwaahịa nucleic acid ahaziri maka mmetụta bioactive kpọmkwem. A na-achịkwa ibu molekul na nguzozi nhazi nke iberibe ahụ nke ọma, na-eme ka ma nha nha na ntinye akpụkpọ ahụ dịkwuo mma. Dịka ihe na-enweghị anụmanụ, RJMPDRN®REC kwekọrọ na ụkpụrụ iwu zuru ụwa ọnụ, na-eme ka a na-anabata ahịa n'ógbè ndị dị mkpa. Usoro mmepụta a na-agbaso ụkpụrụ dị mma siri ike, na-eji usoro ịgbaze na nhicha nke na-enye ịdị mma na-adịgide adịgide, ịdị ọcha dị elu, na ọkọnọ a pụrụ ịtụkwasị obi - na-edozi ọnụ ahịa, usoro ọkọnọ, na nsogbu gburugburu ebe obibi nke mwepụta ọdịnala.
N'ihe gbasara ahụike, RJMPDRN®REC bụ ntụ ntụ ọcha, nke a na-agbaze mmiri nke mejupụtara DNA nwere obere RNA, nke sitere na usoro salmon PDRN, ma nwee oke pH nke 5.0–9.0. A na-ekewa ya dị ka ihe ịchọ mma nke dabara adaba maka iji na emulsions dị elu, ude, ihe mkpuchi anya, ihe mkpuchi ihu, na usoro nlekọta akpụkpọ ahụ ndị ọzọ dị elu. Ọmụmụ In vitro egosila nchekwa na arụmọrụ ya na mkpokọta nke 100–200 μg/mL, na-akwado mmụba nke mkpụrụ ndụ na ọrụ mgbochi mbufụt na-enweghị cytotoxicity.
Ọmụmụ ihe gbasara arụmọrụ na-egosikwa na RJMPDRN nwere ike ịrụ ọrụ nke ọma.®REC. Ọ na-eme ka mbugharị fibroblast dịkwuo mma nke ukwuu, na-enweta ọnụego mmụba nke 131% na awa 41 ma e jiri ya tụnyere njikwa. Banyere njikọ collagen, RJMPDRN®REC na-akwalite collagen ụdị mmadụ nke I ugboro 1.5 na collagen ụdị nke III ugboro 1.1 ma e jiri ya tụnyere njikwa, na-arụ ọrụ karịa PDRN sitere na salmon nkịtị. Na mgbakwunye, ọ na-egbochi nke ukwuu ihe mgbochi mkpali dịka TNF-α na IL-6. Mgbe ejikọtara ya na sodium hyaluronate, , RJMPDRN®REC na-egosipụta mmetụta synergistic, na-eme ka mwepụta nke mkpụrụ ndụ dịkwuo elu, na-egosi ike siri ike maka nhazi mmekorita na nlekọta akpụkpọ ahụ na-agbanwe agbanwe na mgbochi ịka nká.
Na nchịkọta, RJMPDRN®REC nwere mmụba teknụzụ site na mwepụta ọdịnala gaa na njikọta bayọlọjik, na-enye ihe ọzọ a pụrụ imegharị, dị ọcha, na nke na-adịgide adịgide maka usoro nlekọta akpụkpọ ahụ dị elu. Ọ na-egosipụta ọrụ bioactivity, profaịlụ nchekwa, na nhazi ya na-etinye ya dị ka ihe dị mkpa maka ngwaahịa ịchọ mma na-elekwasị anya na mgbochi ịka nká, ndozi akpụkpọ ahụ, na ahụike akpụkpọ ahụ dum, na-ekwekọ nke ọma na ọchịchọ na-agbanwe agbanwe maka ihe ịchọ mma na-adịgide adịgide na nke sayensị kwadoro.
Pịa ebe a ka ịmatakwu gbasara ngwaahịa a.
Oge ozi: Ọgọst-28-2025